Brain-Gut Interactions in Inflammatory Bowel Disease
نویسندگان
چکیده
منابع مشابه
Brain-gut interactions in inflammatory bowel disease.
Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves interactions among the neural components, including (1) the autonomic nervous system, (2) the central nervous system, (3) the stress system (hypothalamic-pituitary-adrenal axis), (4) the (gastrointestinal) corticotropin-re...
متن کاملBrain-Gut Interactions in Inflammatory Bowel Diseases
Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel diseases (IBD). The brain-gut axis involves interactions between the neural components including; a) the autonomic nervous system, b) the central nervous system c) the stress system (hypothalamic-pituitary adrenal axis, HPA) and d) the (i.e. gastro-intestinal) cort...
متن کاملGut Microbiota in Inflammatory Bowel Disease
The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of "dysbiosis", with alterations of the gut microbial...
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Background: Clinical and experimental observations in animal models indicate that intestinal commensal bacteria are involved in the initiation and amplification of inflammatory bowel disease (IBD). No paediatric reports are available on intestinal endogenous microflora in IBD. Aims: To investigate and characterise the predominant composition of the mucosa-associated intestinal microflora in col...
متن کاملHost-bacterial interactions in inflammatory bowel disease.
Large numbers of different bacterial species are resident in the lumen of the distal gastrointestinal tract. The normal intestinal host-microbial interactions are not well understood, but the relationship is generally believed to be either mutually beneficial or beneficial to one without disadvantage to the other. Animal model and clinical studies suggest that IBD (inflammatory bowel disease) m...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2013
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2012.10.003